Nanoparticles in Medicine by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9789811389542
Publisher: Springer Singapore

4.4.2 Antifungal Properties

In addition to their effective antibacterial activity, AgNPs are also act as potent fungicides. They are highly toxic against a broad class of pathogenic fungi that includes the genera of Aspergillus, Saccharomyces, Candida and Trichoderma (Reddy 2015). AgNPs between 2 and 100 nm size range with the minimal inhibitory concentration of 0.4–100 ug/ml showed antifungal properties (Reddy 2015). Even though the fungicide activity of AgNPs is not fully understood, studies report that their mechanism of action is similar to their antibacterial activity (Wright et al. 1999). AgNPs synthesized from Alternaria alternata showed the antifungal activity against Phoma glomerata, Phoma herbarum, Fusarium semitectum, Trichoderma sp., and C. albicans. Thus synergistic antifungal effects of AgNPs with fluconazole were observed (Gajbhiye et al. 2009). Similarly, AgNPs synthesized using Amylomyces rouxii showed the antifungal activity against F. oxysporum and C. albicans (Musarrat et al. 2010).

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